This study is to evaluate the cytotoxicity of mitomycin C(MMC) and its analogue 5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole-4,7-dione(629) as well as the effect of transfection of constitutive androstane receptor(CAR) on their biological effects. 研究丝裂霉素C(MMC)及其衍生物5-氮丙啶-3-羟甲基-1-甲基吲哚-4,7-二酮[5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole-4,7-dione,629]的细胞毒性,以及结构性雄烷受体(constitutive androstane receptor,CAR)转染对其生物学效应的影响。
