The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
RNF4 has been implicated in transcriptional regulation through interacting with a variety of nuclear proteins, and functions as a transcriptional corepressor or coactivator. RNF4被认为是转录机制中的协同抑制因子或是活化因子。
Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR). 近来的有关表皮干细胞分化的途径的工作基于分析细胞核受体辅阻遏物HR的体内作用的研究。
Gene expression of nuclear receptor corepressor in androgen independent prostate cancer and its clinical significance 核受体辅阻遏子在雄激素非依赖性前列腺癌中的表达及临床意义
