Microcystins are hepatotoxin released by harmful toxic cyanobacterial bloom, are the potential risk factor of natural envi ronment and human health. 微囊藻毒素是有毒蓝藻释放的肝毒性代谢物，对环境和人们健康具有潜在危害，成为各国普遍关注的热点，并已列入我国地表水环境质量特定检测项目。
Alcohol, the most common cause, is a hepatotoxin that interferes with mitochondrial and microsomal function in hepatocytes, leading to an accumulation of lipid. 乙醇是最常见的病因，作为肝毒素能阻碍肝细胞内的线粒体和微粒体的功能，导致脂质沉集。
Useful in vivo models for testing of antifibrotics are rat secondary biliary fibrosis or the MDR2 KO mouse (chronic cholestatic liver disease)and reversion of fibrosis after withdrawal of a hepatotoxin like thioacetamide. 用于检测抗肝纤维化药物有效性的动物模型包括继发性大鼠胆汁性肝纤维化或者MDR2 KO小鼠模型(慢性淤胆性肝病)以及撤药以后可逆性的肝毒性肝纤维化如硫代乙酰胺肝纤维化模型。
