The results of our study demonstrate that, at dopamine tachyphylaxis of canine tracheal smooth muscle, histamine treatment could recover the contraction to dopamine. 研究结果显示，除了增强多巴胺引致的收缩外，组织胺处理亦可在狗气管平滑肌对多巴胺反应疲乏时恢复肌肉对多巴胺收缩的能力。
Short term tolerance can be caused by depleted levels of neurotransmitters within the vesicles available for release into the synaptic cleft following subsequent reuse (tachyphylaxis). 在多次重复用药后（快速抗药反应），由于在细胞囊中神经传递素的大幅降低，而不能释放到神经键隙，也会造成短期抗药性。
