In this article a new kind of inclusion complex involving carbenoxolone sodium and pseduoephedrine was synthesized. 合成了甘珀酸钠和右旋麻黄碱的包合物。
AIM: To explore the effects of carbenoxolone (CBX), a gap junction blocker, on the neuron injury induced by focal cerebral infarct. 目的 :探讨缝隙连接阻断剂甘珀酸对大鼠光化学局灶性脑梗死神经元损害的影响 .
Methods: Experimental rats were intrathecally injected with carbenoxolone(CBX), a special gap junction blocker, and the control rats with the saline. 方法 :向实验组大鼠鞘内注射一种缝隙连接的阻断剂甘珀酸 ;
Results The acute toxicity of LD50 of the clathrate compound in 1:1, 1:2 and 2:1 were lower than that of both carbenoxolone sodium and oxymatrine. 结果 甘珀酸钠苦参素1:1、1:2、2:1包合物的急性毒性均比其前体药物甘珀酸钠、苦参素低；
Objective To study the acute toxicity of clathrate compound of carbenoxolone and oxymatrine and its protectire effects on injured liver induced by CCl4 in mice. 目的 研究甘珀酸钠苦参素包合物急性毒性及对CCl4肝损伤小鼠的保护作用。
Objective To observe the expression of connexin-32 and glial fibrillary acidic protein (GFAP)and their mutual relationship in forebrain of pentylenetetrazol (PTZ) induced seizure in rats after pretreatment with carbenoxolone (CBX). 目的研究大鼠在脑室埋管注射甘珀酸(CBX)预处理后戊四氮导致癫痫发作时前脑内胶质纤维酸性蛋白(GFAP)和连接蛋白-32(Cx32)表达及其相互关系。
