Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis. 这样的脾肿大通常预示有骨髓增生型疾病，例如慢性髓性白血病或骨髓纤维化。
Mayo Clinic researchers reviewed records of 311 patients with primary myelofibrosis, a scarring of the bone marrow, from 1976 to 2006. 梅奥诊所的研究人员审查记录的311例原发性骨髓纤维化，疤痕的骨髓，从1976年至2006年。
Results Twenty patients were diagnosed as portal hypertension.Most of these patients suffered from lymphoma or myelofibrosis. 结果有20例诊为门脉高压症，导致门脉高压症的血液病主要是淋巴瘤和骨髓纤维化。
Myelofibrosis with myeloid metaplasia:pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly. 慢性特发性骨髓纤维化病理分型与临床预后的关系。
Patients with primary myelofibrosis feel fatigued, and they sometimes take an anemia drug to stimulate growth of oxygen-carrying red blood cells. 例原发性骨髓纤维化感到疲倦，他们有时会采取贫血的药物，以刺激经济增长的载氧量，血液中的红细胞。
Classic MPDs comprise four subtypes: chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (CIMF). 慢性粒细胞白血病(CML)、真性红细胞增多症(PV)、原发性血小板增多症(ET)、慢性特发性骨髓纤维化(CIMF)均归于典型MPD；
